Yatvin M B, Abdel-Halim M N
Strahlentherapie. 1978 Jun;154(6):419-23.
The mechanism(s) by which gamma radiation influences liver polyribosome distribution was studied in groups of intact and adrenalectomized male rats. The animals were divided among four subgroups: (1) control; (2) irradiation only; (3) cortisone only; (4) irradiation plus cortisone. Analysis of the liver polyribosome distribution patterns indicated that a shift from light to heavy aggregates occurred in both intact and adrenalectomized rats after they were exposed to gamma rays. In irradiated adrenalectomized rats, however, the shift to heavier aggregates was not as great as that which occurred in irradiated adrenal-intact animals. Subcutaneous injection of cortisone acetate (10 mg/100 g body weight) also altered the liver polyribosome patterns of both intact and adrenalectomized rats within 8 hours of its administration. The shift which occurred following cortisone administration, however, was less striking than that seen after irradiation only. Thus, although adrenal glucocorticoids contribute to the radiation induced shift in liver polyribosomes in adrenal intact rats, other factors appear to be involved, since the shift is also obtained in adrenalectomized animals.
在完整和肾上腺切除的雄性大鼠组中研究了γ辐射影响肝脏多核糖体分布的机制。动物被分为四个亚组：(1) 对照组；(2) 仅照射组；(3) 仅注射可的松组；(4) 照射加可的松组。肝脏多核糖体分布模式分析表明，完整和肾上腺切除的大鼠在受到γ射线照射后，均出现了从轻度聚集物向重度聚集物的转变。然而，在接受照射的肾上腺切除大鼠中，向较重聚集物的转变不如在接受照射的肾上腺完整动物中明显。皮下注射醋酸可的松（10毫克/100克体重）在给药后8小时内也改变了完整和肾上腺切除大鼠的肝脏多核糖体模式。然而，可的松给药后发生的转变不如仅照射后明显。因此，尽管肾上腺糖皮质激素在肾上腺完整的大鼠中有助于辐射诱导的肝脏多核糖体转变，但其他因素似乎也参与其中，因为在肾上腺切除的动物中也观察到了这种转变。
