Dusheiko A A, Khmutovakiĭ O A, Blazhevich M A, Solodova E V, Chernukhina L A, Zabeliu E M
Ukr Biokhim Zh (1978). 1978 May-Jun;50(3):325-31.
In the intermediate area of the chicken stomach with A-avitaminosis the amount of the secretion increases and its chemical composition changes sharply: the content of water, lipids, hexolamines and suphates lowers. By means of 14-C-acetate, 35S-methionine and 35S-sulphate it is established that renewal of the secretion is inhibited. The electron-microscopic examinations showed that the secret is homogenous in normalcy but with A-avitaminosis it acquires a honeycomb structure, its physicochemical properties being changed: it becomes rigid, cuticle-like. As a result there appear deep cracks reaching mucosa, which lead to formation of erosions and ulcers. An assumption is advanced that the initial disturbances of the secretion might be not related to protein component (as the ratio of amino acids in it's almost unchanged) and depend on the carbohydrate and lipid components. The hypothesis of de Luc et al. as to the transport and intermediatory function of vitamin A in biosynthesis of glycosamineglycanes, glycolipids and glycolipoproteins is questioned. Vitamin A may take part in these processes but not as an intermediator of metabolic systems but as the level of biological structures (for instance, the Golgi apparatus and others) which organize these systems and coordinate their function.
在患有维生素A缺乏症的鸡胃中间区域，分泌量增加，其化学成分发生急剧变化：水、脂质、己糖胺和硫酸盐的含量降低。通过14-C-醋酸盐、35S-蛋氨酸和35S-硫酸盐证实，分泌物的更新受到抑制。电子显微镜检查表明，正常情况下分泌物是均匀的，但在维生素A缺乏症时，它获得了蜂窝状结构，其物理化学性质发生了变化：它变得坚硬，类似角质层。结果出现了深达黏膜的裂缝，导致糜烂和溃疡的形成。有人提出假设，分泌物的最初紊乱可能与蛋白质成分无关（因为其中氨基酸的比例几乎不变），而是取决于碳水化合物和脂质成分。德吕克等人关于维生素A在氨基聚糖、糖脂和糖脂蛋白生物合成中的运输和中介功能的假设受到质疑。维生素A可能参与这些过程，但不是作为代谢系统的中介，而是作为组织这些系统并协调其功能的生物结构（例如高尔基体等）的水平。
