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[维生素A缺乏时胃黏膜表面上皮的超微结构组织]

[Ultrastructural organization of the surface epithelium of gastric mucosa in vitamin A deficiency].

作者信息

Gulich M P, Onoprienko E N

出版信息

Arkh Anat Gistol Embriol. 1990 Nov;99(11):72-5.

PMID:2090048
Abstract

Under conditions of experimental A-avitaminosis in cells of superficial epithelium of the chicken stomach mucous membrane certain ultrastructural changes of cytoplasmic membranes takes place. Amount of transport vesicles decreases, regeneration of membranes in the Golgi complex cisterns, secretory vesicles and apical part of the external cellular membrane with development of apical erosions is disturbed. The problem on influence of the changes mentioned to the process of mucus formation, in particular to protein glycosylation in the Golgi complex is discussed. Insufficient vitamin A amount, getting into the organism results in a decreased resistivity of the stomach mucous membrane as a consequence of disturbances in processes of mucus formation and in safety of the apical part of the external cellular membrane of the superficial epithelium.

摘要

在鸡胃黏膜表层上皮细胞实验性维生素A缺乏的条件下,细胞质膜会发生某些超微结构变化。运输小泡数量减少,高尔基体池、分泌小泡和细胞外膜顶端部分的膜再生受到干扰,同时顶端糜烂加剧。文中讨论了上述变化对黏液形成过程的影响,特别是对高尔基体中蛋白质糖基化的影响。机体摄入维生素A不足会导致胃黏膜抵抗力下降,这是由于黏液形成过程受到干扰以及表层上皮细胞外膜顶端部分的安全性受到影响所致。

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