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组蛋白H1的内源性核小体超（ADP-核糖基）化与染色质松弛诱导之间的相关性。

Correlation between endogenous nucleosomal hyper(ADP-ribosyl)ation of histone H1 and the induction of chromatin relaxation.

作者信息

Aubin R J, Fréchette A, de Murcia G, Mandel P, Lord A, Grondin G, Poirier G G

出版信息

EMBO J. 1983;2(10):1685-93. doi: 10.1002/j.1460-2075.1983.tb01643.x.

DOI:10.1002/j.1460-2075.1983.tb01643.x
PMID:6641701
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC555344/
Abstract

The effect of poly(ADP-ribose) synthesis on chromatin structure was investigated by velocity sedimentation and electron microscopy. We demonstrate that locally relaxed regions can be generated within polynucleosome chains by the activity of their intrinsic poly(ADP-ribose)polymerase. This relaxation phenomenon is also shown to be NAD dependent and to be correlated with the formation of hyper(ADP-ribosyl)ated forms of histone H1. Evidence is also presented which suggests that hyper(ADP-ribosyl)ated histone H1 is neither released from the relaxed chromatin, nor does it seem to participate in polynucleosomal aggregation.

摘要

通过速度沉降和电子显微镜研究了聚（ADP - 核糖）合成对染色质结构的影响。我们证明，在多核小体链内，其内在的聚（ADP - 核糖）聚合酶的活性可产生局部松弛区域。这种松弛现象还显示出依赖于NAD，并与组蛋白H1的高（ADP - 核糖基）化形式的形成相关。还提供了证据表明，高（ADP - 核糖基）化的组蛋白H1既不会从松弛的染色质中释放出来，也似乎不参与多核小体的聚集。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/989e/555344/b3c87d8936b5/emboj00263-0071-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/989e/555344/635944b00d7d/emboj00263-0067-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/989e/555344/c2f6ff57d7ac/emboj00263-0068-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/989e/555344/c746bed46c9e/emboj00263-0069-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/989e/555344/c8f0991334f3/emboj00263-0070-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/989e/555344/b3c87d8936b5/emboj00263-0071-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/989e/555344/635944b00d7d/emboj00263-0067-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/989e/555344/c2f6ff57d7ac/emboj00263-0068-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/989e/555344/c746bed46c9e/emboj00263-0069-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/989e/555344/c8f0991334f3/emboj00263-0070-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/989e/555344/b3c87d8936b5/emboj00263-0071-a.jpg

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Correlation between endogenous nucleosomal hyper(ADP-ribosyl)ation of histone H1 and the induction of chromatin relaxation.组蛋白H1的内源性核小体超（ADP-核糖基）化与染色质松弛诱导之间的相关性。
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2
The structure of histone H1 and its location in chromatin.组蛋白H1的结构及其在染色质中的位置。
Nature. 1980 Dec 25;288(5792):675-9. doi: 10.1038/288675a0.
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Characterization of a putative poly(adenosine diphosphate ribose)-chromatin complex.一种假定的聚（二磷酸腺苷核糖）-染色质复合物的表征
铝暴露下斑马鱼脑内聚（二）ADP-核糖的合成与降解
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Characterizing crosstalk in epigenetic signaling to understand disease physiology.描述表观遗传信号转导中的串扰，以了解疾病生理学。
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