Harvard Stem Cell Institute, Harvard Medical School, Boston, MA 02115, USA.
Beth Israel Deaconess Medical Center, Department of Medicine, Harvard Medical School, Boston, MA 02215, USA.
Genes (Basel). 2021 Mar 20;12(3):446. doi: 10.3390/genes12030446.
ADP-ribosylation, is a reversible post-translational modification implicated in major biological functions. Poly ADP-ribose polymerases (PARP) are specialized enzymes that catalyze the addition of ADP ribose units from "nicotinamide adenine dinucleotide-donor molecules" to their target substrates. This reaction known as PARylation modulates essential cellular processes including DNA damage response, chromatin remodeling, DNA methylation and gene expression. Herein, we discuss emerging roles of PARP1 in chromatin remodeling and epigenetic regulation, focusing on its therapeutic implications for cancer treatment and beyond.
ADP-核糖基化是一种涉及重要生物学功能的可逆翻译后修饰。聚 ADP-核糖聚合酶 (PARP) 是一种特殊的酶，可催化从“烟酰胺腺嘌呤二核苷酸供体分子”向其靶底物添加 ADP 核糖单位。该反应称为 PAR 化，可调节包括 DNA 损伤反应、染色质重塑、DNA 甲基化和基因表达在内的基本细胞过程。本文讨论了 PARP1 在染色质重塑和表观遗传调控中的新作用，重点关注其在癌症治疗及其他领域的治疗意义。
