Bienenstock J, Befus D, McDermott M, Mirski S, Rosenthal K
Fed Proc. 1983 Dec;42(15):3213-7.
A fundamentally important factor in the expression of immunity at mucosal sites is the migration of primed lymphocytes to, from, and among mucosal tissues. Despite considerable information in recent years on the selective localization of B lymphoblasts, especially those destined to make IgA antibodies in mucosal tissues, the basis for this remains obscure. Several cell-associated factors such as surface characteristics, histo-compatibility type, and organ derivation of the cells play a significant role for T and B lymphoblast localization. Factors that regulate lymphoblast delivery to tissues, such as blood flow, or control emigration from tissues, such as arachidonic acid metabolites, are discussed. Finally, factors such as the presence or absence of high endothelial venules, isotype-specific T helper cells, sex hormones, antigen, macrophages, and iron all may play a significant role in mucosal lymphoblast localization.
黏膜部位免疫表达的一个根本重要因素是致敏淋巴细胞在黏膜组织之间、从黏膜组织以及向黏膜组织的迁移。尽管近年来关于B淋巴母细胞的选择性定位，尤其是那些注定要在黏膜组织中产生IgA抗体的B淋巴母细胞，已有大量信息，但这一现象的基础仍不清楚。几种细胞相关因素，如细胞的表面特征、组织相容性类型和器官来源，对T和B淋巴母细胞的定位起着重要作用。文中讨论了调节淋巴母细胞向组织输送的因素，如血流，或控制从组织中移出的因素，如花生四烯酸代谢产物。最后，诸如高内皮微静脉的有无、同型特异性T辅助细胞、性激素、抗原、巨噬细胞和铁等因素，都可能在黏膜淋巴母细胞定位中发挥重要作用。
