Feder H H, Goy R W
Horm Behav. 1983 Sep;17(3):284-91. doi: 10.1016/0018-506x(83)90027-2.
Female guinea pigs were treated with 200 micrograms estradiol dipropionate (ED) daily from Days 1 to 15 of life. As adults they all ovulated. After gonadectomy and estrogen-progesterone treatment in adulthood, lordosis behavior was evident and showed no decrements (compared with neonatally oil-treated controls) except for a marginal decrease in maximum duration scores. However, testosterone propionate treatment in adulthood significantly increased mounting behavior in neonatally ED-treated females compared to the controls. On the other hand, estrogen-progesterone treatment in adulthood stimulated mounting in the neonatally oil-treated group, but not in the neonatally estrogenized group. The results suggest that at least some aspects of steroid-dependent behaviors can be permanently influenced by estrogen treatment after the presumed prenatal critical period for sexual differentiation has been completed in guinea pigs.
从出生第1天到第15天，每天给雌性豚鼠注射200微克二丙酸雌二醇（ED）。成年后，它们均排卵。成年后进行性腺切除和雌激素 - 孕酮处理后，除最大持续时间得分略有下降外，脊柱前凸行为明显且无减退（与新生期接受油处理的对照组相比）。然而，与对照组相比，成年后丙酸睾酮处理显著增加了新生期接受ED处理的雌性豚鼠的骑跨行为。另一方面，成年后雌激素 - 孕酮处理刺激了新生期接受油处理组的骑跨行为，但对新生期接受雌激素处理组无此作用。结果表明，在豚鼠假定的性分化产前关键期结束后，雌激素处理可对至少某些类固醇依赖性行为的方面产生永久性影响。
