Harvey L A, Caldicott W J
Invest Radiol. 1983 Sep-Oct;18(5):441-4. doi: 10.1097/00004424-198309000-00007.
We have examined the effect of dose on contrast medium-induced reductions in glomerular filtration in anesthetized rabbits. The fraction of renal plasma flow that is filtered, the filtration fraction, was directly measured by the renal arteriovenous difference method using technetium-99m (99mTc) (Sn) DTPA as the tracer, arterial and renal venous extracorporeal shunts, a gamma camera and a computer. Filtration fraction (FF) was measured each 30 seconds before and after contrast medium (sodium/methylglucamine diatrizoate) was injected in 15 seconds at a dose of 0.5, 1.0 or 2.0 ml/kg, IV. In six animals that had a control FF of 0.19 +/- 0.01 there was a dose-related decrease in FF. The largest dose reduced FF by 53.3%. In three other animals that had a low control FF (0.07 +/- 0.01), the largest dose induced an even greater 71.0% decrease in FF. These data suggest that attempts at increasing contrast excretion by injecting larger doses will be offset, at least in part, by larger reductions in glomerular filtration, and that this effect may be greater when glomerular function is impaired.
我们研究了剂量对造影剂所致麻醉兔肾小球滤过率降低的影响。使用锝-99m（99mTc）（锡）二乙三胺五乙酸（DTPA）作为示踪剂，通过动脉和肾静脉体外分流、γ相机和计算机，采用肾动静脉差法直接测量被滤过的肾血浆流量分数，即滤过分数。在以0.5、1.0或2.0毫升/千克的剂量于15秒内静脉注射造影剂（泛影葡胺钠/葡甲胺）之前和之后，每30秒测量一次滤过分数（FF）。在6只对照滤过分数为0.19±0.01的动物中，滤过分数呈剂量相关下降。最大剂量使滤过分数降低了53.3%。在另外3只对照滤过分数较低（0.07±0.01）的动物中，最大剂量使滤过分数降低得更多，达71.0%。这些数据表明，试图通过注射更大剂量来增加造影剂排泄，至少部分会被肾小球滤过更大幅度的降低所抵消，并且当肾小球功能受损时，这种影响可能更大。
