Mates S L, Lund J S
J Comp Neurol. 1983 Nov 20;221(1):91-7. doi: 10.1002/cne.902210107.
This study continues an investigation (Mates and Lund, '83a) of neuronal development in lamina 4C of macaque monkey striate visual cortex. The maturational history of the type 1 synaptic contacts on spine-bearing stellate neurons, which comprise 95% of the neurons of the lamina, is described. It is shown that type 1 contacts are initially found on the dendritic shafts; these contacts appear to be carried out on spine outgrowths. This leads to the adult condition where type 1 contacts are found only on the spine tips. A similar phenomenon has been reported for pyramidal neurons of the rat (reported during the course of this study by Miller and Peters, '81). In later maturation the spine and its type 1 contact may be lost; profiles found in the neuropil illustrate a process of shrinkage and detachment of both the type 1 axon terminals and postsynaptic dendritic spines in normal maturation. These findings provide an explanation for the marked increase and decrease in spine populations observed to occur on these neurons during normal maturation in an earlier study by Boothe et al. ('79).
本研究延续了一项关于猕猴纹状视觉皮层4C层神经元发育的调查（Mates和Lund，1983a）。描述了占该层神经元95%的有棘星状神经元上1型突触接触的成熟过程。结果表明，1型接触最初出现在树突干上；这些接触似乎是在棘突生长时形成的。这导致了成年状态，即仅在棘突尖端发现1型接触。大鼠锥体神经元也有类似现象（在本研究过程中由Miller和Peters于1981年报道）。在后期成熟过程中，棘突及其1型接触可能会丢失；神经毡中发现的轮廓说明了正常成熟过程中1型轴突终末和突触后树突棘的收缩和脱离过程。这些发现为Boothe等人（1979）早期研究中观察到的这些神经元在正常成熟过程中棘突数量显著增加和减少提供了解释。
