Zimmerman C L, Slattery J T
J Pharm Sci. 1983 Nov;72(11):1262-6. doi: 10.1002/jps.2600721107.
A general approach to the selection of the maintenance dose (Dm) required to give a desired steady-state concentration of drug based on a single determination of concentration after a test dose (C*) is extended to drugs with two-compartment pharmacokinetic characteristics. Using the equation developed, the value of the proportionality factor relating 1/Dm to C was found to be within 3.2% of the value calculated from a published nomogram for lithium. The inherent error is shown to be a function of the value of the hybrid rate constants alpha and beta, as well as the value of an intercompartmental transfer rate constant, k21, in an individual.
一种基于单次试验剂量后浓度测定值（C*）来选择达到所需药物稳态浓度所需维持剂量（Dm）的通用方法被扩展到具有二室药代动力学特征的药物。利用所推导的方程，发现将1/Dm与C相关联的比例因子的值与根据已发表的锂元素列线图计算出的值相差在3.2%以内。内在误差显示为个体中混合速率常数α和β的值以及隔室间转运速率常数k21值的函数。
