Dawling S, Ford S, Ariyanayagam P, O'Neal H, Lewis R R
Clin Pharmacokinet. 1987 Jan;12(1):73-8. doi: 10.2165/00003088-198712010-00005.
Plasma mianserin and desmethylmianserin concentrations were measured in 17 clinically depressed elderly patients after a single 30 mg dose of mianserin. The patients then received mianserin 30 mg daily for up to 6 weeks and the plasma concentrations were measured at weekly intervals. The relationship between concentrations of mianserin and desmethylmianserin at steady-state and at 16 and 24 hours after the single test dose was not good enough to be used for prediction of dosage requirements. Reasons for this finding are discussed.
对17例临床诊断为抑郁症的老年患者单次服用30毫克米安色林后，测定其血浆米安色林和去甲基米安色林浓度。然后患者每天服用30毫克米安色林，持续6周，并每周测定血浆浓度。单次试验剂量后16小时和24小时以及稳态时米安色林和去甲基米安色林浓度之间的关系不足以用于预测剂量需求。讨论了这一发现的原因。
