Lundbeck F, Mogensen P, Jeppesen N
J Urol. 1983 Dec;130(6):1087-9. doi: 10.1016/s0022-5347(17)51698-5.
A double-blind investigation was done on 44 patients with noninvasive bladder tumors (stage Ta) given randomized intravesical treatment with doxorubicin with or without urokinase. The bladder tumors were not removed before treatment in any patient. No significant difference in response was detected between the 2 types of treatment. Of the patients 86 per cent responded to treatment, including 52 per cent who achieved complete remission. At 12 and 42 months after termination of treatment 42 and 35 per cent of the patients, respectively, remained free of recurrent tumor.
对44例非浸润性膀胱肿瘤（Ta期）患者进行了一项双盲研究，这些患者被随机给予膀胱内注射阿霉素，部分患者同时加用尿激酶。所有患者在治疗前均未切除膀胱肿瘤。两种治疗方式在疗效上未检测到显著差异。86%的患者对治疗有反应，其中52%达到完全缓解。在治疗结束后的12个月和42个月时，分别有42%和35%的患者无肿瘤复发。
