Okamoto M, Hayashi K
J Theor Biol. 1983 Oct 21;104(4):591-8. doi: 10.1016/0022-5193(83)90247-3.
The dynamic behavior of cyclic enzyme systems where two enzymes share a substrate or cofactor in a cyclic manner is investigated by computer simulation. The dynamic characteristics of cyclic enzyme systems display catastrophic behavior in response to specific changes in external input without assuming allosteric regulation.
通过计算机模拟研究了两种酶以循环方式共享底物或辅因子的循环酶系统的动态行为。循环酶系统的动态特性在不假设变构调节的情况下,对外部输入的特定变化表现出灾难性的行为。