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地磁干扰后小鼠夜间吗啡镇痛作用减弱。

Reduced nocturnal morphine analgesia in mice following a geomagnetic disturbance.

作者信息

Ossenkopp K P, Kavaliers M, Hirst M

出版信息

Neurosci Lett. 1983 Oct 10;40(3):321-5. doi: 10.1016/0304-3940(83)90059-9.

DOI:10.1016/0304-3940(83)90059-9
PMID:6646507
Abstract

Latency to respond to an aversive thermal stimulus and the degree of analgesia induced by morphine were examined in mice injected with either isotonic saline or morphine sulfate (10 mg/kg) during midscotophase of a 12:12 h LD cycle. When mean response latencies were compared to the degree of geomagnetic disturbance (Ap index) present on test days, it was found that during the geomagnetic storm on December 17th, 1982, a significant reduction (P less than 0.01) in response latency was evident in both saline- and morphine-treated mice. The reduction in response latencies was greater, and lasted longer in the morphine-treated animals. It is suggested that the pineal gland may mediate this biomagnetic effect.

摘要

在12:12小时光照/黑暗周期的暗期中期,给注射了等渗盐水或硫酸吗啡(10毫克/千克)的小鼠检测对厌恶性热刺激的反应潜伏期以及吗啡诱导的镇痛程度。当将平均反应潜伏期与测试日存在的地磁干扰程度(Ap指数)进行比较时,发现1982年12月17日地磁风暴期间,盐水处理组和吗啡处理组小鼠的反应潜伏期均显著缩短(P小于0.01)。吗啡处理组动物的反应潜伏期缩短幅度更大,且持续时间更长。提示松果体可能介导了这种生物磁效应。

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