• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

[在o,p-二氯二苯二氯乙烷作用下犬肾上腺皮质中电子顺磁共振细胞色素P-450、肾上腺皮质铁氧化还原蛋白和自由基信号强度的降低]

[Decrease in the intensity of the EPR cytochrome P-450, adrenodoxine and free radical signals in the adrenal cortex of dogs under the effect of o,p-dichlorodiphenyldichloroethane].

作者信息

Mikosha A S, Berezovskaia N N

出版信息

Probl Endokrinol (Mosk). 1983 Sep-Oct;29(5):62-5.

PMID:6647432
Abstract

A study was made of the action of the adrenocorticolytic drug chloditane (o.p'-DDD) on the content of cytochrome P-450 adrenodoxine and free radicals in the dog adrenal cortex. After a single feeding of 50 mg/kg bw o.p'-DDD EPR signals with xi-factors 2.25, 1.94 and 2.00 reduced 30-40%. Three-fold feeding of the drug in a dose of 100 mg/kg bw produced a further demonstrable decrease of signals. These changes attest to a possible inhibition of the hydroxylase complex in the adrenal cortex induced by o.p'-DDD.

摘要

研究了肾上腺皮质溶解药物氯地孕酮（邻对二氯二苯二氯乙烷，o.p'-DDD）对犬肾上腺皮质中细胞色素P-450、肾上腺皮质激素和自由基含量的作用。单次喂食50mg/kg体重的o.p'-DDD后，g因子为2.25、1.94和2.00的电子顺磁共振（EPR）信号降低了30-40%。以100mg/kg体重的剂量三次喂食该药物后，信号进一步明显降低。这些变化证明o.p'-DDD可能抑制肾上腺皮质中的羟化酶复合物。

相似文献

1
[Decrease in the intensity of the EPR cytochrome P-450, adrenodoxine and free radical signals in the adrenal cortex of dogs under the effect of o,p-dichlorodiphenyldichloroethane].[在o,p-二氯二苯二氯乙烷作用下犬肾上腺皮质中电子顺磁共振细胞色素P-450、肾上腺皮质铁氧化还原蛋白和自由基信号强度的降低]
Probl Endokrinol (Mosk). 1983 Sep-Oct;29(5):62-5.
2
Treatment with o,p'-DDD (mitotane) decreased cytochrome P-450, heme, and microsomal protein content in the dog adrenal cortex in vivo.
Res Commun Chem Pathol Pharmacol. 1976 Jan;13(1):83-92.
3
[Action of chloditane on the phospholipid composition of the adrenals in dogs].[氯地坦对犬肾上腺磷脂成分的作用]
Farmakol Toksikol. 1983 Jul-Aug;46(4):65-8.
4
[Insensitivity of purified glutathione reductase from adrenal cortex to o,p'-dichlorodiphenyldichloroethane].[肾上腺皮质纯化谷胱甘肽还原酶对o,p'-二氯二苯二氯乙烷不敏感]
Ukr Biokhim Zh (1978). 1982 Jul-Aug;54(4):400-4.
5
[The effect of o,p'-dichlorodiphenyldichloroethane on malic enzyme activity of the adrenal glands].[邻对二氯二苯二氯乙烷对肾上腺苹果酸酶活性的影响]
Vopr Med Khim. 1985 Jan-Feb;31(1):61-4.
6
[Changes in mitochondrial and microsomal electron transport as affected by o,p'-dichlorodiphenyldichloroethane].[线粒体和微粒体电子传递的变化受邻，对'-二氯二苯二氯乙烷的影响]
Ukr Biokhim Zh (1978). 1981 Nov-Dec;53(6):74-7.
7
Covalent binding of o,p'-DDD in rabbit lung and isolated rabbit lung cells.o,p'-滴滴滴在兔肺及分离的兔肺细胞中的共价结合。
Toxicol Lett. 1990 Oct;53(3):297-306. doi: 10.1016/0378-4274(90)90234-d.
8
Cytochrome P450-catalyzed binding of 3-methylsulfonyl-DDE and o,p'-DDD in human adrenal zona fasciculata/reticularis.细胞色素P450催化3-甲基磺酰基-DDE和邻，对'-滴滴滴在人肾上腺束状带/网状带中的结合。
J Clin Endocrinol Metab. 2002 Mar;87(3):1319-26. doi: 10.1210/jcem.87.3.8281.
9
[Activity of glutathione reductase in the adrenal glands and the liver of dogs after administration O,P-DDD, perthane and ACTH].[给予O,P-DDD、过氯乙烯和促肾上腺皮质激素后犬肾上腺和肝脏中谷胱甘肽还原酶的活性]
Probl Endokrinol (Mosk). 1978 Jan-Feb;24(1):95-8.
10
The in vitro metabolism of 1-(o-chlorophenyl)-1-(p-chlorophenyl)-2,2-dichloroethane (o,p'-DDD) by dog adrenal mitochondria and metabolite covalent binding to mitochondrial macromolecules: a possible mechanism for the adrenocorticolytic effect.
Drug Metab Dispos. 1977 Sep-Oct;5(5):482-6.