Douville Y, Johnston K W, Kassam M, Zuech P, Cobbold R S, Jares A
Ultrasound Med Biol. 1983 Jul-Aug;9(4):347-56. doi: 10.1016/0301-5629(83)90087-x.
A new in vitro model has been developed for studying the changes in the ultrasound Doppler spectrum that occur in the region of a stenosis. Pulsatile flow in rigid acrylic tubes was produced by means of a modified hemodialysis pump. The Doppler spectral waveforms were measured using a continuous wave Doppler system, a probe of a known field pattern, a real-time high resolution frequency analyzer, and a video display and recording system. The flow velocity waveforms were found to be nearly identical to those seen in the human carotid. Measurements were made to determine the critical stenosis and the results are similar to those reported from in vivo studies. In a preliminary study, the extent of spectral broadening was found to be dependent on the recording site in relation to the stenosis, the severity of the stenosis, and the flow rate. Using qualitative methods it was not possible to determine either the influence of the shape of the stenosis or the phase of the cardiac cycle on spectral broadening.
已开发出一种新的体外模型，用于研究狭窄区域内超声多普勒频谱的变化。通过改良的血液透析泵在刚性丙烯酸管中产生脉动流。使用连续波多普勒系统、已知场型探头、实时高分辨率频率分析仪以及视频显示和记录系统来测量多普勒频谱波形。发现流速波形与在人体颈动脉中观察到的波形几乎相同。进行测量以确定临界狭窄，结果与体内研究报告的结果相似。在一项初步研究中，发现频谱展宽的程度取决于相对于狭窄的记录部位、狭窄的严重程度和流速。使用定性方法无法确定狭窄形状或心动周期相位对频谱展宽的影响。
