Stromberg P C, Rosol T J, Grants I S, Mezza L E
Department of Veterinary Pathobiology, Ohio State University, Columbus.
Vet Pathol. 1992 May;29(3):216-22. doi: 10.1177/030098589202900305.
Twenty-two congenitally athymic nude (rnu/rnu) rats were transplanted with large granular lymphocyte leukemia derived from F344 rats and then compared with ten similar rats inoculated with a suspension of normal F344 rat spleen cells. The normal spleen cells and tumor cells from a spontaneous, naturally occurring leukemia did not grow or cause clinical disease in any of the rats. All rats inoculated with a serially passaged leukemia cell inoculum had local growth at the inoculation site that spread widely and resulted in progressive tumor growth. Death occurred between 16 and 38 days after inoculation. The 22 rats that received passaged tumor cells developed leukemia and splenomegaly. Spleens were diffusely infiltrated by tumor cells and had severe depletion of lymphocytes in the white pulp. Leukemic rats were thrombocytopenic and had hemolytic anemia characterized by increased osmotic fragility, red cell width, and many nucleated erythrocytes. The disease syndrome appears similar to that of F344 rats transplanted with the same inoculum. Because the host rats lacked T cells, it is concluded that the hemolytic anemia and thrombocytopenia that develop in transplanted rats are independent of T cell function.
将22只先天性无胸腺裸鼠（rnu/rnu）移植源自F344大鼠的大颗粒淋巴细胞白血病，然后与10只接种正常F344大鼠脾细胞悬液的类似大鼠进行比较。正常脾细胞和源自自发性、自然发生白血病的肿瘤细胞在任何一只大鼠中均未生长或引发临床疾病。所有接种连续传代白血病细胞接种物的大鼠在接种部位均出现局部生长，且广泛扩散，导致肿瘤进行性生长。接种后16至38天之间发生死亡。接受传代肿瘤细胞的22只大鼠发生白血病和脾肿大。脾脏被肿瘤细胞弥漫性浸润，白髓中的淋巴细胞严重耗竭。白血病大鼠出现血小板减少，并伴有溶血性贫血，其特征为渗透脆性增加、红细胞宽度增加以及出现许多有核红细胞。该疾病综合征似乎与移植相同接种物的F344大鼠的疾病综合征相似。由于宿主大鼠缺乏T细胞，因此得出结论，移植大鼠中发生的溶血性贫血和血小板减少与T细胞功能无关。
