Robinson K S, Kavlock R J, Watkinson W P
Am J Obstet Gynecol. 1983 Dec 1;147(7):795-8. doi: 10.1016/0002-9378(83)90041-8.
Uterine ischemia results in severe cardiac disturbances in the fetus. It has been postulated that these effects are due to interaction between the fetus and the ischemic uterus or placenta, and not to hypoxia or buildup of metabolites in the fetus. Rat fetal cardiac responses to uterine clamping and umbilical cord clamping were compared by electrocardiography. On day 21 of gestation, fetuses in a total of 14 pregnant rats were exposed to umbilical clamping, uterine clamping, or no clamping. Electrocardiograms were recorded for each fetus immediately after clamping and at 10, 20, and 30 minutes after clamping. Immediately after clamping, the uterine clamping group alone showed severe sinus bradycardia. At all other observation times, fetuses exposed to uterine or umbilical clamping showed bradycardia and other electrocardiographic changes typically associated with hypoxia. Therefore, umbilical clamping protected the fetuses from the adverse effects of uterine clamping for only a very short time.
子宫缺血会导致胎儿出现严重的心脏紊乱。据推测，这些影响是由于胎儿与缺血的子宫或胎盘之间的相互作用，而非胎儿的缺氧或代谢产物的积累。通过心电图比较了大鼠胎儿对子宫钳夹和脐带钳夹的心脏反应。在妊娠第21天，总共14只怀孕大鼠中的胎儿分别接受脐带钳夹、子宫钳夹或不钳夹处理。在钳夹后立即以及钳夹后10、20和30分钟为每个胎儿记录心电图。钳夹后立即，仅子宫钳夹组出现严重窦性心动过缓。在所有其他观察时间，接受子宫或脐带钳夹的胎儿均出现心动过缓和其他通常与缺氧相关的心电图变化。因此，脐带钳夹仅在很短的时间内保护胎儿免受子宫钳夹的不利影响。
