Claudy A L, Gagnaire D
Arch Dermatol. 1983 Dec;119(12):975-8.
Twenty-three patients with alopecia areata were treated with photochemotherapy combining oral or topical methoxsalen and UV-A irradiation of the scalp or of the whole body. Eleven of 17 patients with multiple plaques of alopecia areata, alopecia totalis, and alopecia universalis, who were treated with oral methoxsalen and total body irradiation, had complete or more than 90% hair regrowth. Three patients had a relapse. The mean energy required was 505 joules/sq cm. In six cases, topical applications of methoxsalen or oral methoxsalen combined with local irradiation of the scalp were treatment failures. In the patients responding to treatment, the result did not seem to depend on the age of onset or the extent or duration of disease. However, patients with long-lasting alopecia had a higher risk of recurrence notwithstanding a good initial regrowth of hair. Few side effects of psoralens and UV-A (PUVA) treatment were noted. The mean follow-up period was 18.6 months after the completion of treatment. We discuss the possible mechanisms of action of PUVA in the treatment of alopecia areata.
23例斑秃患者接受了光化学疗法，该疗法联合口服或外用甲氧沙林以及对头 皮或全身进行紫外线A（UV-A）照射。17例患有多发性斑秃斑片、全秃和普秃的患者接受了口服甲氧沙林和全身照射，其中11例实现了完全或超过90%的头发生长。3例出现复发。所需的平均能量为505焦耳/平方厘米。6例患者外用甲氧沙林或口服甲氧沙林联合头皮局部照射治疗失败。在对治疗有反应的患者中，结果似乎不取决于发病年龄或疾病的范围或持续时间。然而，尽管初始头发生长良好，但长期脱发的患者复发风险更高。补骨脂素和UV-A（PUVA）治疗的副作用很少。治疗结束后的平均随访期为18.6个月。我们讨论了PUVA治疗斑秃的可能作用机制。
