Moszczyński P, Lisiewicz J
Arch Immunol Ther Exp (Warsz). 1983;31(2):171-6.
The activity and intracellular localization of lysosomal acid phosphatase in lymphocytes was studied in 170 healthy subjects of various age using semiquantitative cytochemical method. The groups studied included the premature and term infants, children and adults. During fetal development the gradual organization of enzyme-positive lysosomal granules within lymphocytes occurs and subsequent five decades of life are characterized by stabilization of lysosomal apparatus of these cells. In last decades of life, between 60 and 90, the destabilization and destruction of acid-phosphatase-positive lysosomal granules is observed.
采用半定量细胞化学方法，对170名不同年龄段的健康受试者淋巴细胞中溶酶体酸性磷酸酶的活性和细胞内定位进行了研究。研究组包括早产儿、足月儿、儿童和成年人。在胎儿发育过程中，淋巴细胞内酶阳性溶酶体颗粒逐渐形成，随后的五十年中，这些细胞的溶酶体装置保持稳定。在生命的最后几十年，即60至90岁之间，可观察到酸性磷酸酶阳性溶酶体颗粒的不稳定和破坏。
