Pitt E, Lewis D A, Offord R E
Biochem Pharmacol. 1983 Nov 15;32(22):3355-8. doi: 10.1016/0006-2952(83)90362-3.
Corticosteroid esters have been encapsulated into intact erythrocytes and used as an intravenous treatment for adjuvant induced arthritis in the rat. The treatment consisted of injections of the encapsulated steroids with the effects monitored for up to 14 days. On an equivalent weight basis both encapsulated cortisol-21-phosphate and prednisolone-21-sodium hemisuccinate proved superior to the free steroid esters administered in solution by injection.
皮质类固醇酯已被包裹于完整的红细胞中，并被用作大鼠佐剂性关节炎的静脉治疗药物。治疗方法为注射包裹有类固醇的红细胞，并对疗效进行长达14天的监测。在同等重量的基础上，包裹的21-磷酸皮质醇和半琥珀酸泼尼松龙-21-钠均被证明比注射溶液中的游离类固醇酯更具优势。
