Newman R J, Radda G K
Br J Pharmacol. 1983 Jun;79(2):395-9. doi: 10.1111/j.1476-5381.1983.tb11011.x.
Phosphorus nuclear magnetic resonance (n.m.r.) spectroscopy is a recently introduced method for the non-invasive study of muscle biochemistry. It was shown in the rat that an intramuscular injection of the drug resulted in degeneration that was reflected spectroscopically in a progressive decrease in the intracellular concentrations of phosphocreatine and adenosine triphosphate without a corresponding rise in that of inorganic phosphate. Furthermore, ATP was depleted in the presence of significant levels of phosphocreatine. As regeneration occurred spectra returned to normal and this was complete by day 10. No such spectroscopic effects were demonstrated in man following the use of bupivacaine in an intravenous regional anaesthetic. It is suggested that further studies in man are required before this drug can be administered intramuscularly with confidence.
磷核磁共振（n.m.r.）光谱学是一种最近引入的用于肌肉生物化学非侵入性研究的方法。在大鼠实验中发现，肌肉内注射该药物会导致肌肉退化，这在光谱上表现为磷酸肌酸和三磷酸腺苷的细胞内浓度逐渐降低，而无机磷酸盐的浓度却没有相应升高。此外，在磷酸肌酸水平显著的情况下，三磷酸腺苷会被耗尽。随着再生的发生，光谱恢复正常，到第10天完全恢复。在人体中，使用布比卡因进行静脉区域麻醉后，未观察到这种光谱效应。建议在能够放心地进行该药物的肌肉注射之前，需要对人体进行进一步研究。
