Smith G, Elton R A, Beynon L L, Newsam J E, Chisholm G D, Hargreave T B
Br J Urol. 1983 Dec;55(6):665-9. doi: 10.1111/j.1464-410x.1983.tb03400.x.
Quadrant biopsies of normal-looking mucosa were used as part of the assessment of cases with superficial Ta,T1 transitional cell cancer of the bladder. Patients with one or more abnormal biopsies were shown to have a significantly greater chance of developing recurrent tumour compared to patients with normal mucosal biopsy findings. Other factors noted at the time of initial assessment, such as size, number of tumours, Ta,T1 category or grade of tumour did not predict recurrence, although recurrences that invaded muscle were associated with G3 histology in the primary tumour. The results of mucosal biopsy identified patients at risk for recurrence and it is possible that this group would derive particular benefit from adjuvant chemotherapy.
对外观正常的黏膜进行象限活检，作为膀胱浅表Ta、T1期移行细胞癌病例评估的一部分。与黏膜活检结果正常的患者相比，有一处或多处活检异常的患者发生肿瘤复发的几率显著更高。初始评估时记录的其他因素，如肿瘤大小、数量、Ta、T1分期或肿瘤分级，并不能预测复发，尽管侵犯肌肉的复发与原发肿瘤的G3组织学相关。黏膜活检结果可识别出有复发风险的患者，这组患者可能会从辅助化疗中特别获益。
