Oliver R T, Hope-Stone H F, Blandy J P
Br J Urol. 1983 Dec;55(6):760-3. doi: 10.1111/j.1464-410x.1983.tb03421.x.
Analysis of patients with germ cell tumours of the testis treated at the London Hospital during the last 30 years has shown that the incidence of pure seminoma has fallen from 69 to 39%. Coincident with this, the incidence of patients with metastases detectable at presentation in all other types of germ cell tumour has increased from 19 to 62%. These observations may explain why the relapse rate of the most recently treated patients with Stage 1 malignant teratoma was the same whether or not they received prophylactic radiotherapy and substantially less than that reported in the literature 30 years ago for orchiectomy alone. These changes justify the use of a surveillance policy for Stage 1 tumour in studies by specialist centres.
对伦敦医院过去30年收治的睾丸生殖细胞瘤患者的分析表明，纯精原细胞瘤的发病率已从69%降至39%。与此同时，在所有其他类型的生殖细胞瘤中，初诊时可检测到转移的患者发病率从19%增至62%。这些观察结果或许可以解释，为何对于近期接受治疗的1期恶性畸胎瘤患者，无论是否接受预防性放疗，其复发率相同，且远低于30年前文献中仅行睾丸切除术的报告。这些变化证明了专科中心在研究中对1期肿瘤采用监测策略的合理性。
