Thomas R, Dearnaley D, Nicholls J, Norman A, Sampson S, Horwich A
Academic Urology Unit, Royal Marsden NHS Trust, Sutton, Surrey, UK.
Br J Cancer. 1996 Jul;74(1):59-62. doi: 10.1038/bjc.1996.315.
We analysed 973 patients with stage I testicular tumours presenting between 1983 and 1994. The median ages at presentation for non-seminomatous germ cell tumour (teratoma) were 27 years, seminoma 36 years and combined tumour 33 years. These differences were statistically significant (Mann-Whitney P < 0.05), suggesting that combined tumours may have a separate natural history. We, therefore, analysed all stage I patients managed with surveillance (530 in total) post orchidectomy. The actuarial 5 year relapse-free survival and anatomical patterns of relapse were identical for non-seminomatous germ cell tumour (NSGCT) and combined tumour and both were statistically distinct from seminoma (P = 0.01, log-rank test, chi-square test P = 0.001). The association of seminoma within a histologically confirmed NSGCT has no influence on the clinical outcome.
我们分析了1983年至1994年间出现的973例I期睾丸肿瘤患者。非精原细胞瘤性生殖细胞肿瘤（畸胎瘤）出现时的中位年龄为27岁，精原细胞瘤为36岁，混合性肿瘤为33岁。这些差异具有统计学意义（曼-惠特尼检验P<0.05），表明混合性肿瘤可能有独立的自然病程。因此，我们分析了所有接受睾丸切除术后进行观察的I期患者（共530例）。非精原细胞瘤性生殖细胞肿瘤（NSGCT）和混合性肿瘤的精算5年无复发生存率及复发的解剖学模式相同，且两者在统计学上均与精原细胞瘤不同（P = 0.01，对数秩检验，卡方检验P = 0.001）。在组织学确诊的NSGCT中精原细胞瘤的存在对临床结果没有影响。
