Moulin D, Paty D W, Ebers G C
Brain. 1983 Dec;106 ( Pt 4):809-16. doi: 10.1093/brain/106.4.809.
We undertook a prospective study of 183 patients with monosymptomatic demyelination to determine the predictive value of the finding of cerebrospinal oligoclonal banding (OB) for the subsequent development of clinically definite multiple sclerosis. The results of this study indicate that patients with monosymptomatic demyelination who are OB positive are at significantly higher risk than those who are OB negative to develop clinically disseminated disease over the period of follow-up in this study. Positive OB is associated with a higher frequency of electrophysiological abnormalities than negative OB, suggesting that OB development correlates with the degree of biological dissemination. The observation that some patients develop OB during the course of the disease has practical implications for the follow-up of patients with unifocal disease and negative banding.
我们对183例单症状脱髓鞘患者进行了一项前瞻性研究，以确定脑脊液寡克隆区带（OB）检测结果对于后续发展为临床确诊多发性硬化症的预测价值。本研究结果表明，在本研究的随访期间，单症状脱髓鞘且OB阳性的患者发生临床播散性疾病的风险显著高于OB阴性患者。与OB阴性相比，OB阳性与更高频率的电生理异常相关，这表明OB的出现与生物学播散程度相关。一些患者在疾病过程中出现OB这一观察结果，对于单病灶疾病且区带检测阴性患者的随访具有实际意义。
