Thompson A J, Hutchinson M, Martin E A, Mansfield M, Whelan A, Feighery C
J Neurol Neurosurg Psychiatry. 1985 Oct;48(10):989-94. doi: 10.1136/jnnp.48.10.989.
CSF immunoglobulins were examined in 103 patients with clinically definite multiple sclerosis, 106 patients with either suspected or progressive possible multiple sclerosis and 72 patients with other neurological diseases. Raised CSF IgG index and oligoclonal banding were found in 71% and 75% of clinically definite multiple sclerosis patients respectively and both tests were abnormal in 11% of patients with other neurological diseases. The CSF IgG index and the presence of oligoclonal IgG did not relate to the severity or duration of established disease in these patients. In patients with suspected and progressive possible multiple sclerosis, both a raised IgG index and the presence of oligoclonal banding were found significantly more frequently than in the OND group. Abnormalities of these parameters were significantly correlated with the presence of an abnormal evoked response in these patients (chi 2 = 10.16 p less than 0.01). When 47 patients with suspected multiple sclerosis were studied prospectively the presence of oligoclonal banding at presentation was associated with development of further disease activity.
对103例临床确诊的多发性硬化患者、106例疑似或进展性可能的多发性硬化患者以及72例患有其他神经系统疾病的患者进行了脑脊液免疫球蛋白检测。临床确诊的多发性硬化患者中，分别有71%和75%的患者脑脊液IgG指数升高和出现寡克隆带，在患有其他神经系统疾病的患者中，两项检测均异常的占11%。这些患者的脑脊液IgG指数和寡克隆IgG的存在与已确诊疾病的严重程度或病程无关。在疑似和进展性可能的多发性硬化患者中，IgG指数升高和寡克隆带的出现显著多于其他神经系统疾病组。这些参数的异常与这些患者中异常诱发电位的存在显著相关（χ² = 10.16，p < 0.01）。对47例疑似多发性硬化患者进行前瞻性研究时，初诊时寡克隆带的存在与进一步疾病活动的发生有关。
