经口和非肠道给予丙卡巴肼诱导大鼠体细胞产生的特定基因座突变。
Specific locus mutations induced in somatic cells of rats by orally and parenterally administered procarbazine.
作者信息
Maier P, Zbinden G
出版信息
Science. 1980 Jul 11;209(4453):299-301. doi: 10.1126/science.7384804.
PMID:7384804
Abstract
A new test, the granuloma pouch assay, was used in detecting specific locus mutations in somatic cells of rats in vivo after the animals were treated orally and parenterally with procarbazine hydrochloride, an agent used in cancer chemotherapy. The results indicate that stable intermediates are formed in the body and distributed as proximate mutagens.
摘要
一种新的检测方法，即肉芽肿袋试验，被用于检测大鼠体细胞中的特定基因座突变。这些大鼠经口服和注射盐酸丙卡巴肼（一种癌症化疗药物）进行处理。结果表明，体内形成了稳定的中间体，并作为直接诱变剂进行分布。
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