赭曲霉毒素A代谢产物对酵母苯丙氨酰-tRNA合成酶以及肝癌细胞生长和体内蛋白质合成的影响。
Effects of ochratoxin A metabolites on yeast phenylalanyl-tRNA synthetase and on the growth and in vivo protein synthesis of hepatoma cells.
作者信息
Creppy E E, Størmer F C, Kern D, Röschenthaler R, Dirheimer G
出版信息
Chem Biol Interact. 1983 Nov;47(2):239-47. doi: 10.1016/0009-2797(83)90160-6.
PMID:6652810
Abstract
The ochratoxin A (OTA) metabolite (4R)-4-hydroxyochratoxin A [4R)-OTA) inhibits the aminoacylation of phenylalanine tRNA catalyzed by phenylalanyl-tRNA synthetase (PheRS) with a Ki-value of 0.9 mM as compared to 1.3 mM for OTA. It also inhibits protein synthesis and cell growth in the same manner as OTA. Ochratoxin alpha (OT alpha) does not affect either protein synthesis or cell growth.
摘要
赭曲霉毒素A（OTA）的代谢产物（4R）-4-羟基赭曲霉毒素A [（4R）-OTA] 抑制苯丙氨酰-tRNA合成酶（PheRS）催化的苯丙氨酸tRNA的氨酰化反应，其抑制常数（Ki值）为0.9 mM，而OTA的Ki值为1.3 mM。它还以与OTA相同的方式抑制蛋白质合成和细胞生长。赭曲霉毒素α（OTα）对蛋白质合成或细胞生长均无影响。
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