综述：赭曲霉毒素A毒性研究中的表观遗传机制
A Review: Epigenetic Mechanism in Ochratoxin A Toxicity Studies.
作者信息
Zhu Liye, Zhang Boyang, Dai Yaqi, Li Hongyu, Xu Wentao
机构信息
Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science & Nutritional Engineering, China Agricultural University, Beijing 100083, China.
Beijing Laboratory for Food Quality and Safety, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China.
出版信息
Toxins (Basel). 2017 Mar 23;9(4):113. doi: 10.3390/toxins9040113.
Ochratoxin A (OTA) is a natural contaminant that has displayed nephrotoxicity and hepatotoxicity in mammals. It contaminates a great variety of foodstuffs and threatens people's lives. The molecular mechanism of OTA-induced toxicity has been studied since 1965. Moreover, epigenetic mechanisms are also studied in OTA-induced toxicity. Additionally, the mode of OTA epigenetic research has been advanced in research hotspots. However, there is still no epigenetic study of OTA-induced toxicity. In this review, we discuss the relationship between these epigenetic mechanisms and OTA-induced toxicity. We found that studies on the epigenetic mechanisms of OTA-induced toxicity all chose the whole kidney or liver as the model, which cannot reveal the real change in DNA methylation or miRNAs or histone in the target sites of OTA. Our recommendations are as follows: (1) the specific target site of OTA should be detected by advanced technologies; and (2) competing endogenous RNAs (ceRNA) should be explored with OTA.
赭曲霉毒素A（OTA）是一种天然污染物，已在哺乳动物中表现出肾毒性和肝毒性。它污染多种食品，威胁人们的生命。自1965年以来，人们一直在研究OTA诱导毒性的分子机制。此外，也对OTA诱导毒性中的表观遗传机制进行了研究。另外，OTA表观遗传研究的模式在研究热点方面也有所进展。然而，目前仍没有关于OTA诱导毒性的表观遗传学研究。在本综述中，我们讨论了这些表观遗传机制与OTA诱导毒性之间的关系。我们发现，关于OTA诱导毒性表观遗传机制的研究均选择全肾或肝脏作为模型，这无法揭示OTA靶位点处DNA甲基化、微小RNA（miRNAs）或组蛋白的真实变化。我们的建议如下：（1）应采用先进技术检测OTA的特定靶位点；（2）应探索OTA与竞争性内源性RNA（ceRNA）之间的关系。
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