Nishikawa T, Tanaka M, Tsuda A, Kohno Y, Nagasaki N
Eur J Pharmacol. 1983 Oct 14;94(1-2):53-8. doi: 10.1016/0014-2999(83)90441-7.
The role of serotonergic neurons in foot shock-induced jumping behavior was evaluated by studying the effects of serotonin agonists and depletors under conditions of increasing activity of catecholaminergic neurons by combining different shock intensities with methamphetamine or clonidine pretreatment. Low shock (40 V) jumping was suppressed by three different kinds of serotonergic agonists: 5-hydroxytryptophan (50 and 100 mg/kg), 5-methoxydimethyltryptamine (1 and 5 mg/kg) and clomipramine (5 mg/kg) but these drugs did not suppress high shock (60 V) jumping. A depletor of brain serotonin, p-chlorophenylalanine (200 mg/kg), failed to affect the jumping induced by both shock intensities. The inhibitory effect of serotonergic agonists on low shock jumping was abolished by pretreatment with methamphetamine (1 mg/kg) or clonidine (100 micrograms/kg). Furthermore, 5-methoxydimethyltryptamine (5 mg/kg), a serotonergic postsynaptic receptor stimulant, potentiated high shock jumping in rats pretreated with methamphetamine (3 and 5 mg/kg). The results indicated that activation of serotonergic neurons has a differential effect on jumping behavior ranging from inhibitory to facilitatory, depending upon the increasing activity of catecholaminergic neurons.
通过结合不同的电击强度与甲基苯丙胺或可乐定预处理，在增加儿茶酚胺能神经元活性的条件下，研究5-羟色胺激动剂和5-羟色胺消耗剂的作用，以评估5-羟色胺能神经元在足部电击诱发的跳跃行为中的作用。三种不同的5-羟色胺能激动剂：5-羟色氨酸（50和100mg/kg）、5-甲氧基二甲基色胺（1和5mg/kg）和氯米帕明（5mg/kg）可抑制低强度电击（40V）诱发的跳跃，但这些药物对高强度电击（60V）诱发的跳跃没有抑制作用。一种脑5-羟色胺消耗剂，对氯苯丙氨酸（200mg/kg），未能影响两种电击强度诱发的跳跃。甲基苯丙胺（1mg/kg）或可乐定（100μg/kg）预处理可消除5-羟色胺能激动剂对低强度电击跳跃的抑制作用。此外，一种5-羟色胺能突触后受体刺激剂，5-甲氧基二甲基色胺（5mg/kg），可增强甲基苯丙胺（3和5mg/kg）预处理大鼠的高强度电击跳跃。结果表明，5-羟色胺能神经元的激活对跳跃行为具有不同的影响，从抑制到促进，这取决于儿茶酚胺能神经元活性的增加。
