Yamada T, Uchida H, Ichikawa A
Jikken Dobutsu. 1983 Jul;32(3):107-13.
We examined the ability of learning and its retention employing test with the water T-maze, shuttle box and passive avoidance response (PAR) in offspring from mother rats treated with N-methylnitrosourea (MNU) or chlorpromazine (CPZ). The offspring of MNU-induced learning impairments were detected only in tests with the water T-maze and PAR. On the other hand, CPZ induced impairments were detectable only in tests with the shuttle box and PAR. Thus offspring from mother rats treated with MNU or CPZ showed partially different responses. In retention tests, both MNU and CPZ caused impaired ability in the water T-maze and PAR. In the PAR test, impairment was most clearly detectable. From these results, the PAR test appears to be the most useful method in detection of impairments in learning and retention ability, especially the latter, in the reproduction test of offspring.
我们使用水迷宫、穿梭箱和被动回避反应（PAR）测试，研究了用N-甲基亚硝基脲（MNU）或氯丙嗪（CPZ）处理的母鼠后代的学习能力及其保持情况。仅在水迷宫和PAR测试中检测到MNU诱导的学习障碍后代。另一方面，CPZ诱导的障碍仅在穿梭箱和PAR测试中可检测到。因此，用MNU或CPZ处理的母鼠后代表现出部分不同的反应。在保持测试中，MNU和CPZ均导致水迷宫和PAR中的能力受损。在PAR测试中，损伤最明显可检测到。从这些结果来看，PAR测试似乎是在后代繁殖测试中检测学习和保持能力损伤，尤其是后者的最有用方法。
