Zaĭtsev A A, Bershadskiĭ B G
Farmakol Toksikol. 1983 Nov-Dec;46(6):29-32.
It has been shown in experiments on conscious cats with the aid of multifactorial analysis that the main effects of phentanyl given in doses of 15 and 30 micrograms/kg on the systemic hemodynamics proved to be hypertensive and tachycardic. One of the mechanisms of the chronotropic effect of the drug was partially realized through the inhibition of the baroreceptor reflex. The individual characteristics of the hemodynamic effect of the analgetic depended on the animals' initial status and might be predicted thereby.
在清醒猫身上进行的实验借助多因素分析表明，剂量为15和30微克/千克的芬太尼对全身血流动力学的主要影响被证明是高血压和心动过速。该药物变时效应的机制之一部分是通过抑制压力感受器反射实现的。镇痛药血流动力学效应的个体特征取决于动物的初始状态，因此可以由此预测。
