Karai I, Sugimoto K, Goto S
Int Arch Occup Environ Health. 1983;53(2):91-9. doi: 10.1007/BF00378421.
In order to clarify the pathogenesis of carbon disulfide retinopathy, fluorescein fundus angiograms were analyzed for 143 workers exposed to CS2 and 40 unexposed workers (reference) from viscose rayon factories. Retinal abnormalities, characterized by saccular microaneurysms, ellipsoidal microaneurysms and loop formation of small vessels, and atrophic/degenerative changes of pigmentary epithelium, were found in workers exposed to CS2. Saccular microaneurysms were found in 45.5% of the CS2 workers and 7.5% of the reference workers (P less than 0.05). Ellipsoidal microaneurysms or loop formation were found in 14.0% of the CS2 workers and 5.0% of the reference workers. Atrophic/degenerative changes of the pigmentary epithelium were found in 32.9% of the CS2 workers and 15.0% of the reference workers (P less than 0.05). Significant correlations were found between the prevalence of these retinal abnormalities and the CS2 exposure index.
为阐明二硫化碳视网膜病变的发病机制，对来自粘胶人造丝工厂的143名接触二硫化碳的工人和40名未接触二硫化碳的工人（对照组）进行了荧光素眼底血管造影分析。在接触二硫化碳的工人中发现了视网膜异常，其特征为囊状微动脉瘤、椭圆形微动脉瘤和小血管环形成，以及色素上皮的萎缩/退行性改变。45.5%的接触二硫化碳工人和7.5%的对照组工人发现有囊状微动脉瘤（P<0.05）。14.0%的接触二硫化碳工人和5.0%的对照组工人发现有椭圆形微动脉瘤或血管环形成。32.9%的接触二硫化碳工人和15.0%的对照组工人发现有色素上皮的萎缩/退行性改变（P<0.05）。这些视网膜异常的患病率与二硫化碳暴露指数之间存在显著相关性。
