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本文引用的文献

1
Human tumour xenografts established and serially transplanted in mice immunologically deprived by thymectomy, cytosine arabinoside and whole-body irradiation.在通过胸腺切除、阿糖胞苷和全身照射进行免疫抑制的小鼠体内建立并连续移植的人肿瘤异种移植模型。
Br J Cancer. 1980 Jan;41(1):52-61. doi: 10.1038/bjc.1980.7.
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Potentials and possible pitfalls of human stem cell analysis.人类干细胞分析的潜力与可能存在的问题。
Cancer Chemother Pharmacol. 1981;6(3):227-35. doi: 10.1007/BF00256975.
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Chemosensitivity testing for human brain tumors.人脑肿瘤的化学敏感性测试。
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Radiation and drug response of the rat glioma RG2.
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Activity of two phase I drugs, homoharringtonine and tricyclic nucleotide, against surgical explants of human tumors in the 6-day subrenal capsule assay.两种I期药物高三尖杉酯碱和三环核苷酸在6天肾包膜下试验中对人肿瘤手术外植体的活性。
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6
Chemotherapy responsiveness of human tumors as first transplant generation xenografts in the normal mouse: six-day subrenal capsule assay.作为正常小鼠第一代移植异种移植物的人类肿瘤的化疗反应性：六天肾包膜下测定法
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7
Determinants for the establishment of permanent tissue culture lines from human gliomas.从人脑胶质瘤建立永久性组织培养系的决定因素。
Acta Pathol Microbiol Scand A. 1973 Nov;81(6):791-805. doi: 10.1111/j.1699-0463.1973.tb03573.x.
8
Heterotransplantation of human cancers into nude mice: a model system for human cancer chemotherapy.将人类癌症异种移植到裸鼠体内：一种用于人类癌症化疗的模型系统。
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9
Development of a clonogenic cell assay for human brain tumors.一种用于人类脑肿瘤的克隆形成细胞检测方法的开发。
Cancer. 1978 Jun;41(6):2305-14. doi: 10.1002/1097-0142(197806)41:6<2305::aid-cncr2820410632>3.0.co;2-u.
10
Growth of human tumor xenografts implanted under the renal capsule of normal immunocompetent mice.植入正常免疫活性小鼠肾被膜下的人肿瘤异种移植物的生长情况。
Exp Cell Biol. 1979;47(4):281-93. doi: 10.1159/000162947.

肾包膜下移植法中脑肿瘤的生长及对化疗的反应

Brain tumor growth and response to chemotherapy in the subrenal capsule assay.

作者信息

Weizsäcker M, Nagamune A, Rathmer K, Wechsler W

出版信息

J Cancer Res Clin Oncol. 1983;106(3):229-33. doi: 10.1007/BF00402613.

DOI:10.1007/BF00402613
PMID:6654957
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12253374/
Abstract

Pieces from eight freshly biopsied human gliomas and tumors grown from a human glioma (U118MG) established by transplantation and a rat glioma (RG2) were transplanted under the renal capsule of normal, immunocompetent rats. The effects of chemotherapy administered intraperitoneally to host rats were evaluated by measuring the growth of implanted tumor specimens. Results could be obtained within 7 days of transplantation and suggest that the subrenal capsule assay might be useful in the future for the rapid evaluation of the sensitivity of human brain tumors to therapeutic manipulation. The limitations of the assay are discussed.

摘要

取自8例新鲜活检的人类神经胶质瘤的组织块，以及通过移植建立的人类神经胶质瘤（U118MG）和大鼠神经胶质瘤（RG2）所产生的肿瘤，被移植到正常的、具有免疫活性的大鼠的肾被膜下。通过测量植入肿瘤标本的生长情况，评估对宿主大鼠进行腹腔内化疗的效果。移植后7天内即可获得结果，这表明肾被膜下试验未来可能有助于快速评估人类脑肿瘤对治疗操作的敏感性。本文讨论了该试验的局限性。