肾包膜下移植法中脑肿瘤的生长及对化疗的反应
Brain tumor growth and response to chemotherapy in the subrenal capsule assay.
作者信息
Weizsäcker M, Nagamune A, Rathmer K, Wechsler W
出版信息
J Cancer Res Clin Oncol. 1983;106(3):229-33. doi: 10.1007/BF00402613.
Abstract
Pieces from eight freshly biopsied human gliomas and tumors grown from a human glioma (U118MG) established by transplantation and a rat glioma (RG2) were transplanted under the renal capsule of normal, immunocompetent rats. The effects of chemotherapy administered intraperitoneally to host rats were evaluated by measuring the growth of implanted tumor specimens. Results could be obtained within 7 days of transplantation and suggest that the subrenal capsule assay might be useful in the future for the rapid evaluation of the sensitivity of human brain tumors to therapeutic manipulation. The limitations of the assay are discussed.
摘要
取自8例新鲜活检的人类神经胶质瘤的组织块，以及通过移植建立的人类神经胶质瘤（U118MG）和大鼠神经胶质瘤（RG2）所产生的肿瘤，被移植到正常的、具有免疫活性的大鼠的肾被膜下。通过测量植入肿瘤标本的生长情况，评估对宿主大鼠进行腹腔内化疗的效果。移植后7天内即可获得结果，这表明肾被膜下试验未来可能有助于快速评估人类脑肿瘤对治疗操作的敏感性。本文讨论了该试验的局限性。
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