Nagamachi S, Irie T, Inoue O, Yamasaki T, Ishimatsu K
Radioisotopes. 1983 Aug;32(8):359-63. doi: 10.3769/radioisotopes.32.8_359.
We have developed a production system for 18F-2-deoxy-2-fluoro-D-glucose (18F-2FDG), which assures reliable production with easy handling and reduces radiation exposures to the operator. Chemical procedures in this system are the same as manual method developed in NIRS. This system has 2 operation modes; one is remote controlled manual operation mode and the other is microcomputer controlled automatic operation mode. In remote controlled mode, we tested this system 5 times and 18F-2FDG synthesized was supplied for clinical use once. The mean radiochemical yield of 18F-2FDG from the target gas recovery with decay time correction was 8%, that is the same as in the manual synthesis. It took about 2 hours from end of bombardment (EOB) to end of synthesis (EOS). Since this time is shorter than in manual synthesis, the available activity at EOS is increased.
我们已经开发了一种用于18F-2-脱氧-2-氟-D-葡萄糖（18F-2FDG）的生产系统，该系统确保生产可靠、操作简便，并减少了操作人员所受的辐射暴露。该系统中的化学程序与日本国立放射医学综合研究所开发的手动方法相同。此系统有两种操作模式；一种是遥控手动操作模式，另一种是微机控制自动操作模式。在遥控模式下，我们对该系统进行了5次测试，并将合成的18F-2FDG供应临床使用了一次。经衰变时间校正后，从靶气体回收中获得的18F-2FDG的平均放射化学产率为8%，这与手动合成的产率相同。从轰击结束（EOB）到合成结束（EOS）大约需要2小时。由于这段时间比手动合成短，EOS时的可用活度增加了。
