Singh D K, Agarwal R A
Toxicol Lett. 1983 Dec;19(3):313-9. doi: 10.1016/0378-4274(83)90136-4.
k2, Kd and ki, for 2 organophosphorus (Phorate and Formothion) and 2 carbamate pesticides (Mexacarbate and Carbaryl) using acetylcholinesterase present in homogenates of the nervous tissue of the snail Lymnaea acuminata, were determined. Calculation of zero time velocities demonstrated that even in their P-S form the organophosphate compounds inhibited snail acetylcholinesterase. The kinetic constants of the 2 carbamates have been explained on the basis of their structure. The toxicity of the 4 pesticides has been explained on the basis of their kinetic constants.
利用尖膀胱螺神经组织匀浆中的乙酰胆碱酯酶，测定了2种有机磷农药（甲拌磷和杀螟硫磷）和2种氨基甲酸酯类农药（灭梭威和西维因）的k2、Kd和ki。零时间速度的计算表明，即使处于P-S形式，有机磷化合物也会抑制蜗牛乙酰胆碱酯酶。根据2种氨基甲酸酯类农药的结构对其动力学常数进行了解释。根据4种农药的动力学常数对其毒性进行了解释。
