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肉豆蔻对尖膀胱螺神经组织中杀螺成分的酶抑制作用

Enzyme Inhibition by Molluscicidal Components of Myristica fragrans Houtt. in the Nervous Tissue of Snail Lymnaea acuminata.

作者信息

Jaiswal Preetee, Kumar Pradeep, Singh V K, Singh D K

机构信息

Department of Zoology, D.D.U. Gorakhpur University, Gorakhpur 273009, India.

出版信息

Enzyme Res. 2010;2010:478746. doi: 10.4061/2010/478746. Epub 2009 Dec 6.

DOI:10.4061/2010/478746
PMID:21048864
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2963183/
Abstract

This study was designed to investigate the effects of molluscicidal components of Myristica fragrans Houtt. (Myristicaceae) on certain enzymes in the nervous tissue of freshwater snail Lymnaea acuminata Lamarck (Lymnaeidae). In vivo and in vitro treatments of trimyristin and myristicin (active molluscicidal components of Myristica fragrans Houtt.) significantly inhibited the acetylcholinesterase (AChE), acid and alkaline phosphatase (ACP/ALP) activities in the nervous tissue of Lymnaea acuminata. The inhibition kinetics of these enzymes indicates that both the trimyristin and myristicin caused competitive noncompetitive inhibition of AChE. Trimyristin caused uncompetitive and competitive/noncompetitive inhibitions of ACP and ALP, respectively whereas the myristicin caused competitive and uncompetitive inhibition of ACP and ALP, respectively. Thus results from the present study suggest that inhibition of AChE, ACP, and ALP by trimyristin and myristicin in the snail Lymnaea acuminata may be the cause of the molluscicidal activity of Myristica fragrans.

摘要

本研究旨在探讨肉豆蔻（肉豆蔻科）的杀螺成分对尖膀胱螺（膀胱螺科）神经组织中某些酶的影响。体内和体外给予肉豆蔻酸甘油三酯和肉豆蔻醚（肉豆蔻的活性杀螺成分）均能显著抑制尖膀胱螺神经组织中的乙酰胆碱酯酶（AChE）、酸性和碱性磷酸酶（ACP/ALP）活性。这些酶的抑制动力学表明，肉豆蔻酸甘油三酯和肉豆蔻醚均对AChE产生竞争性非竞争性抑制。肉豆蔻酸甘油三酯分别对ACP和ALP产生非竞争性和竞争性/非竞争性抑制，而肉豆蔻醚分别对ACP和ALP产生竞争性和非竞争性抑制。因此，本研究结果表明，肉豆蔻酸甘油三酯和肉豆蔻醚对尖膀胱螺中AChE, ACP和ALP的抑制作用可能是肉豆蔻具有杀螺活性的原因。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f905/2963183/fc9280c24594/ER2010-478746.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f905/2963183/9088ad881fbc/ER2010-478746.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f905/2963183/70f937bf3f71/ER2010-478746.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f905/2963183/fc9280c24594/ER2010-478746.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f905/2963183/9088ad881fbc/ER2010-478746.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f905/2963183/70f937bf3f71/ER2010-478746.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f905/2963183/fc9280c24594/ER2010-478746.003.jpg

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