Jewo P I, Fadeyibi I O, Babalola O S, Saalu L C, Benebo A S, Izegbu M C, Ashiru O A
Department of Anatomy, Lagos State University College of Medicine (LASUCOM), Ikeja, Lagos, Nigeria.
Ann Burns Fire Disasters. 2009 Jun 30;22(2):79-82.
Burns expose the deeper tissues of the skin or body to invasive microbes. Topical preparations for treating burn wounds, to be useful, should ideally have antibiotic power and promote healing. Silver compounds have been the mainstay of topical burn treatment for decades. However, most chemical substances retard wound healing. Several natural agents such as honey and moist exposed burn ointment (MEBO) are believed to protect wounds from infection and promote healing without causing any of the adverse effects of purified chemicals. In this study, we compared the wound healing properties of MEBO, a herbal preparation of Chinese origin, with silver sulphadiazine (SSD), a long-standing conventional burn dressing. Ten adult Sprague Dawley rats were divided into two groups. They were housed in separate cages and received partial-thickness burn wounds on their dorsal skin. They were then treated with MEBO and SSD. The wounds were inspected daily until day 8, when all the animals were sacrificed, perfused with normal saline, and had their wounds excised and prepared for histology. It was found that animals in both groups were well preserved. No clinical infections occurred. Wound healing was at an advanced stage by day 8 in all the animals. Clinical and histological examination showed that the two agents gave the animals comparable protection and healing possibilities. It is concluded that MEBO is a suitable and efficacious alternative to conventional silver-based topical therapies for treating partial-thickness burn wounds.
烧伤会使皮肤或身体的深层组织暴露于侵入性微生物中。用于治疗烧伤创面的局部制剂若要发挥作用，理想情况下应具备抗菌能力并促进愈合。几十年来，银化合物一直是烧伤局部治疗的主要药物。然而，大多数化学物质会延缓伤口愈合。一些天然制剂，如蜂蜜和湿润烧伤膏（MEBO），被认为可保护伤口免受感染并促进愈合，且不会产生纯化化学物质的任何不良反应。在本研究中，我们将源自中国的草药制剂MEBO与长期使用的传统烧伤敷料磺胺嘧啶银（SSD）的伤口愈合特性进行了比较。将十只成年Sprague Dawley大鼠分为两组。它们被安置在单独的笼子里，并在背部皮肤造成浅Ⅱ度烧伤创面。然后分别用MEBO和SSD进行治疗。每天检查伤口，直至第8天，此时所有动物均被处死，用生理盐水灌注，切除伤口并准备进行组织学检查。结果发现两组动物均保存良好。未发生临床感染。到第8天，所有动物的伤口愈合均处于进展阶段。临床和组织学检查表明，这两种制剂给予动物的保护和愈合可能性相当。得出的结论是，MEBO是治疗浅Ⅱ度烧伤创面的传统银基局部疗法的一种合适且有效的替代方法。
