Noonan F P, Hoffman H A
Department of Dermatology, George Washington University School of Medicine, Washington, DC 20037.
Immunogenetics. 1994;39(1):29-39. doi: 10.1007/BF00171794.
Irradiation with ultraviolet B (UVB; 290-320 nm) initiates systemic immunosuppression of contact hypersensitivity (CHS). UV dose-responses for suppression of CHS to trinitrochlorobenzene were established in 18 strains of inbred mice. Three phenotypes with significantly different susceptibilities to UV suppression were identified. The phenotypes were: high (HI) susceptibility, 50% suppression with 0.7-2.3 kJ/m2 UV (C57BL/6, C57BL/10, and C57L and NZB females); low (LO) susceptibility, 50% suppression with 9.6-12.3 kJ/m2 UV (BALB/c, AKR, SJL and NZW), and intermediate (INT) susceptibility, 50% suppression with 4.7-6.9 kJ/m2 UV (DBA/2, C57BR, C3H/HeJ, C3H/HeN, CBA/N and A/J). UV suppression was not correlated with skin pigmentation or with the magnitude of the CHS response in non-irradiated animals. Major histocompatibility complex (MHC) haplotype was not correlated with UV suppression in MHC congenic strains B10.D2/oSnJ, B10.D2/nSnJ, B10.BR/SgSnJ, and A.BY/SnJ. There were no sex differences in UV suppression in BALB/c, C57BL/6, or NZW animals. In the autoimmune NZB strain, however, male mice (LO) were seven times less sensitive to UV suppression than NZB female mice (HI). Both sexes of (NZB x NZW)F1 and (NZW x NZB)F1 mice were HI, supporting dominance of HI over LO. Thus there are genetic factors and interacting sex-limited factors determining susceptibility to UV suppression. These findings may be of relevance to UV-related diseases such as photosensitive lupus and skin cancer.
用紫外线B（UVB；290 - 320纳米）照射可引发接触性超敏反应（CHS）的全身免疫抑制。在18个近交系小鼠品系中建立了UV对三硝基氯苯所致CHS抑制的剂量反应。鉴定出三种对UV抑制敏感性显著不同的表型。这些表型为：高（HI）敏感性，用0.7 - 2.3千焦/平方米UV照射时抑制率达50%（C57BL/6、C57BL/10、C57L和NZB雌性小鼠）；低（LO）敏感性，用9.6 - 12.3千焦/平方米UV照射时抑制率达50%（BALB/c、AKR、SJL和NZW小鼠），以及中等（INT）敏感性，用4.7 - 6.9千焦/平方米UV照射时抑制率达50%（DBA/2、C57BR、C3H/HeJ、C3H/HeN、CBA/N和A/J小鼠）。UV抑制与皮肤色素沉着或未照射动物的CHS反应强度无关。在MHC同基因品系B10.D2/oSnJ、B10.D2/nSnJ、B10.BR/SgSnJ和A.BY/SnJ中，主要组织相容性复合体（MHC）单倍型与UV抑制无关。在BALB/c、C57BL/6或NZW动物中，UV抑制不存在性别差异。然而，在自身免疫性NZB品系中，雄性小鼠（LO）对UV抑制的敏感性比NZB雌性小鼠（HI）低7倍。（NZB×NZW）F1和（NZW×NZB）F1小鼠的雌雄两性均为HI型，支持HI对LO的显性。因此，存在决定对UV抑制敏感性的遗传因素和相互作用的性别限制因素。这些发现可能与紫外线相关疾病如光敏性狼疮和皮肤癌有关。
