[Structural and regenerative features of the mucosa of the upper portions of the digestive tract in chronic gastritis and peptic ulcer].

For the elucidation of the morphological features of the mucous membrane of the upper parts of the alimentary tract and its capacity for regeneration in chronic gastritis and peptic ulcer 212 patients were examined and among them in 81 gastroesophageal reflux was established. Histological, morphometric, and autoradiographic studies showed morphological changes in the mucous membrane of the esophagus, stomach and duodenum to differ in frequency and pattern in patients with chronic gastritis and peptic ulcer. The presence of the accompanying gastroesophageal reflux in the patients examined caused pathological changes in the esophageal mucosa which were more marked in duodenal ulcer. The observed changes in the histostructure in the upper parts of the alimentary tract occurred during increasing proliferative processes of the epithelial tissue which depended on the age of the patients, duration of the disease and the level of gastric secretion. Morphometric examinations of the mucous membranes of the organs under study revealed the distinguishing features of morphogenesis in diseases of the upper parts of the alimentary tract.