Jacobson K
Cell Motil. 1983;3(5-6):367-73. doi: 10.1002/cm.970030504.
Lateral diffusion measurements, using the photobleaching techniques, have provided unique and quantitative data on the random translational motions of proteins and lipids of membranes. Proper interpretation of this body of data can yield new insight into the structure of biomembranes. A comparative review of the lateral diffusion of membrane components in artificial lipid bilayers and of the same components in natural membranes is presented to demonstrate the effects of protein concentration and peripheral constraints on lateral mobility. Recent data on the effects of cell-substrate and cell-cell contact on lateral diffusion are reviewed. Finally, some experimental perspectives are offered in terms of emerging biophysical and biological technology.
利用光漂白技术进行的侧向扩散测量，已经提供了关于膜蛋白和脂质随机平移运动的独特且定量的数据。对这组数据的恰当解读能够为生物膜的结构带来新的见解。本文对人工脂质双层中膜成分的侧向扩散以及天然膜中相同成分的侧向扩散进行了比较综述，以证明蛋白质浓度和周边限制对侧向迁移率的影响。还综述了关于细胞 - 底物和细胞 - 细胞接触对侧向扩散影响的最新数据。最后，从新兴的生物物理和生物技术角度提供了一些实验观点。
