O'Leary T J
Proc Natl Acad Sci U S A. 1987 Jan;84(2):429-33. doi: 10.1073/pnas.84.2.429.
Lateral diffusion of lipids in biological membranes may be influenced by polypeptides, proteins, and other nonlipid membrane constituents. Using concepts from scaled-particle theory, we extend the free-volume model for lipid diffusion to membranes having an arbitrarily large number of components. This theory clarifies the interpretation of the free-volume theory, better reproduces the free-area dependence of lipid lateral diffusion rates, and quantitatively predicts the experimental observation that the lateral diffusion rates of membrane lipids are significantly reduced when proteins or polypeptides are incorporated in the membrane.
生物膜中脂质的横向扩散可能会受到多肽、蛋白质和其他非脂质膜成分的影响。利用标度粒子理论的概念，我们将脂质扩散的自由体积模型扩展到具有任意大量组分的膜。该理论阐明了自由体积理论的解释，能更好地再现脂质横向扩散速率对自由面积的依赖性，并定量预测了实验观察结果，即当蛋白质或多肽掺入膜中时，膜脂质的横向扩散速率会显著降低。
