6-羟基多巴胺及某些降压药物对大鼠中加压素诱发高血压的影响。
The effect of 6-hydroxydopamine and some hypotensive drugs on lypressin induced hypertension in rats.
作者信息
Szadowska A, Szmigielska H, Szmigielski A, Kamińska A, Wejman I
出版信息
Pol J Pharmacol Pharm. 1985 Jul-Aug;37(4):487-93.
Intracerebroventricular injection of 6-hydroxydopamine (6-OH-DA) prevented the development of the lypressin (LVP)-induced hypertension. Administration of 6-OH-DA to hypertensive rats significantly decreased, but did not normalize, blood pressure. A fourteen-day treatment with clonidine, guanethidine, reserpine, dihydralazine, propranolol and furosemide produced a transient decrease in blood pressure in LVP-hypertensive rats. Eight weeks after the withdrawal of hypotensive drugs blood pressure again reached the value corresponding to that in untreated LVP-hypertensive rats.
脑室内注射6-羟基多巴胺（6-OH-DA）可预防加压素（LVP）诱导的高血压的发展。给高血压大鼠注射6-OH-DA可显著降低血压，但不能使其恢复正常。用可乐定、胍乙啶、利血平、双肼屈嗪、普萘洛尔和呋塞米进行为期14天的治疗，可使LVP高血压大鼠的血压短暂降低。停用降压药8周后，血压再次达到未治疗的LVP高血压大鼠的相应水平。
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