Rissam H S, Nair C R, Anand I S, Madappa C, Wahi P L
Int J Clin Pharmacol Ther Toxicol. 1983 Dec;21(12):602-4.
Antipyrine was used to assess the status of drug metabolism in ten female patients with congestive cardiac failure. Ten age-matched female subjects were used as controls. Patients showed a 40% increase in antipyrine plasma half-life (APH). Elimination constant (Ke) was decreased by 19% in patients as compared to controls. The area under the curve (AUC) was increased by 32% in the patient group. The routine liver function tests did not show any significant alteration in the patients. Increase in APH and AUC and decrease in Ke suggest impaired hepatic drug metabolism in patients with congestive cardiac failure.
使用安替比林评估10例充血性心力衰竭女性患者的药物代谢状况。选取10名年龄匹配的女性受试者作为对照。患者的安替比林血浆半衰期（APH）增加了40%。与对照组相比，患者的消除常数（Ke）降低了19%。患者组的曲线下面积（AUC）增加了32%。常规肝功能检查未显示患者有任何显著变化。APH和AUC增加以及Ke降低表明充血性心力衰竭患者肝脏药物代谢受损。
