Matsuda I, Niimi H, Moritake K, Okumura A, Handa H
Atherosclerosis. 1978 Mar;29(3):363-71. doi: 10.1016/0021-9150(78)90083-7.
In a study on the pathogenesis of arterial wall thickening, hemodynamic factors in the common carotid artery of the rat were experimentally altered with an autograft. The relationship between flow pattern and wall-thickening was examined in a half-ring bypass model with an induced stenosis, using both flow-visualization in a corresponding in vitro model circuit and observation of the wall by microscopy. Wall-thickening was found in the neighborhood of bifurcations, junctions and curved segments, which corresponded to regions of low-shear in the flow-field. Marked histologic changes in the wall were observed in the post-stenotic segments where the flow field was very disturbed. Histologic changes in the arterial wall correlated well with flow patterns.
在一项关于动脉壁增厚发病机制的研究中，通过自体移植对大鼠颈总动脉的血流动力学因素进行了实验性改变。在一个带有诱导性狭窄的半环旁路模型中，利用相应体外模型回路中的血流可视化以及显微镜对血管壁的观察，研究了血流模式与血管壁增厚之间的关系。在分叉、连接处和弯曲段附近发现了血管壁增厚，这些部位对应于流场中的低剪切区域。在狭窄后段观察到血管壁有明显的组织学变化，该区域的流场受到严重干扰。动脉壁的组织学变化与血流模式密切相关。
