Reidy M A, Bowyer D E
Atherosclerosis. 1978 Apr;29(4):459-66. doi: 10.1016/0021-9150(78)90174-0.
Five young male New Zealand White rabbits were fed a semi-synthetic diet containing 0.2% cholesterol for 2 weeks and a control group of 5 animals was fed a normal stock diet. All animals were then injected intravenously with a single dose of endotoxin from Serratia marcescens (200 microgram/kg body weight) and continued on their respective diets for a further 4 weeks. The aortas were then stained with silver nitrate and fixed under pressure for Scanning Electron Microscopy (SEM). Argyrophilic endothelial cells were present in both groups of animals 4 weeks after endotoxin injections. In the cholesterol-fed animals, however, these cells were often covered with pits and craters. These findings suggest that the hypercholesterolaemia may affect the regeneration of arterial endothelial cells.
将五只年轻的雄性新西兰白兔喂食含0.2%胆固醇的半合成饮食，持续两周，同时将五只动物组成的对照组喂食正常的常规饮食。然后所有动物静脉注射单剂量的粘质沙雷氏菌内毒素（200微克/千克体重），并继续各自的饮食，再持续四周。然后将主动脉用硝酸银染色，并在压力下固定以进行扫描电子显微镜（SEM）检查。内毒素注射四周后，两组动物中均存在嗜银内皮细胞。然而，在喂食胆固醇的动物中，这些细胞常常布满凹坑和火山口。这些发现表明，高胆固醇血症可能会影响动脉内皮细胞的再生。
