Cinti S, Enzi G, Cigolini M, Bosello O
Ultrastruct Pathol. 1983 Sep-Oct;5(2-3):145-52. doi: 10.3109/01913128309141834.
The pathogenesis of multiple symmetric lipomatosis (MSL) is as yet unknown; however, some studies seem to indicate the neoplastic nature of this lesion. In this study we have examined the ultrastructural features of the adipocyte precursors of patients with MSL. The cells were isolated by collagenase, cultured, and then examined at the moment of their confluence in a monolayer. Their ultrastructural features were compared with those of cells of the abdominal subcutaneous adipose tissue taken from patients with nonsystemic, surgically treated illnesses. When examined immediately after isolation, the cells from normal tissue did not show significant differences from MSL cells. In culture, however, MSL grew more quickly into a monolayer and showed numerous nuclear pockets and cytoplasmic microfilaments, which were not seen in cells from normal tissue. These differences appear compatible with the neoplastic nature of the MSL adipocyte precursors.
多发性对称性脂肪瘤病（MSL）的发病机制尚不清楚；然而，一些研究似乎表明这种病变具有肿瘤性质。在本研究中，我们检查了MSL患者脂肪细胞前体的超微结构特征。通过胶原酶分离细胞，进行培养，然后在它们汇合形成单层时进行检查。将它们的超微结构特征与取自非全身性手术治疗疾病患者的腹部皮下脂肪组织细胞的特征进行比较。刚分离后检查时，正常组织的细胞与MSL细胞没有显著差异。然而，在培养过程中，MSL细胞生长更快形成单层，并显示出许多核袋和细胞质微丝，而正常组织的细胞中未见这些结构。这些差异似乎与MSL脂肪细胞前体的肿瘤性质相符。
