家族性高胆固醇血症的研究阐明了角膜弓与高脂血症之间的关系。
Relationship between corneal arcus and hyperlipidaemia is clarified by studies in familial hypercholesterolaemia.
作者信息
Winder A F
出版信息
Br J Ophthalmol. 1983 Dec;67(12):789-94. doi: 10.1136/bjo.67.12.789.
Abstract
In subjects with familial hypercholesterolaemia for whom integrated exposure to hyperlipoproteinaemia can be determined, arcus development correlates with age rather than extent or pattern of hyperlipoproteinaemia. This permissive effect whereby arcus development becomes progressively time-dependent rather than dose-dependent at increasing levels of hyperlipoproteinaemia may underlie difficulties in the interpretation of premature corneal arcus in less specific disorders. Arcus development is not apparently influenced by levels of high-density lipoprotein in plasma.
摘要
在能够确定高脂蛋白血症综合暴露情况的家族性高胆固醇血症患者中，角膜弓的形成与年龄相关，而非与高脂蛋白血症的程度或模式相关。在高脂蛋白血症水平不断升高时，角膜弓的形成逐渐变得随时间而变化，而非随剂量而变化，这种允许性效应可能是在不太特异的疾病中解释过早出现的角膜弓存在困难的原因。角膜弓的形成显然不受血浆中高密度脂蛋白水平的影响。
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