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[用于冷却高功率电厂的液体的毒理学特性。II. 通过吸入和皮肤途径测定的毒性]

[Toxicodynamic properties of liquids used for cooling high power plants. II. Toxicity determined by inhalation and dermal routes].

作者信息

Seńczuk W, Florek E

出版信息

Med Pr. 1983;34(5-6):375-9.

PMID:6672524
Abstract

In experiments on toxicity, IWiOL-3-n aerosol as well as vapours and gases obtained by heating the oil up to 500 degrees C were administered by inhalation to experimental animals. No deaths of animals were recorded however, a significant decrease of cholinesterase activity was noted. The experiments were carried out in the specially constructed experimental chambers and the method of determination IWiOL-3-n in the air was developed. After intratracheal insufflation of IWiOL-3-n, rapid decrease of cholinesterase activity in blood serum was also observed. Tests on dermal toxicity showed very good absorption of the oils through the untouched skin.

摘要

在毒性实验中,将IWiOL-3-n气雾剂以及通过将该油加热至500摄氏度所产生的蒸气和气体通过吸入方式给予实验动物。然而,未记录到动物死亡,但观察到胆碱酯酶活性显著下降。实验在专门建造的实验室内进行,并开发了空气中IWiOL-3-n的测定方法。经气管注入IWiOL-3-n后,血清中的胆碱酯酶活性也迅速下降。皮肤毒性试验表明,该油可通过未破损的皮肤被很好地吸收。

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